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báo cáo khoa học: "Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs | Journal of Hematology Oncology BioMed Central Open Access Review Emerging role of Garcinol the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs Subhash Padhye1 2 Aamir Ahmad1 Nikhil Oswal3 and Fazlul H Sarkar 1 Address Department of Pathology Barbara Ann Karmanos Cancer Center and Wayne State University School of Medicine Detroit MI 48201 USA 2D.Y. Patil University of Pharmaceutical Sciences and Research Pune 411018 India and 3D.Y. Patil Institute of Pharmaceutical Sciences and Research Pune 411018 India Email Subhash Padhye - sbpadhye@hotmail.com Aamir Ahmad - ahmada@karmanos.org Nikhil Oswal - oswalnikhil_303@rediffmail.com Fazlul H Sarkar - fsarkar@med.wayne.edu Corresponding author Published 2 September 2009 Received I August 2009 Journal of Hematology Oncology 2009 2 38 doi 10.1186 1756-8722-2-38 Accepted 2 September 2009 This article is available from http www.jhoonline.Org content 2 1 38 2009 Padhye et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Garcinol harvested from Garcinia indica has traditionally been used in tropical regions and appreciated for centuries however its biological properties are only beginning to be elucidated. There is ample data to suggest potent antioxidant properties of this compound which have been used to explain most of its observed biological activities. However emerging evidence suggests that garcinol could be useful as an anti-cancer agent and it is increasingly being realized that garcinol is a pleiotropic agent capable of modulating key regulatory cell signaling pathways. Here we have summarized the progress of our current research knowledge on garcinol and its observed biological activities. We have also provided an explanation of observed .