tailieunhanh - Báo cáo y học: "NGAL: an emerging tool for predicting severity of AKI is easily detected by a clinical assay"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: NGAL: an emerging tool for predicting severity of AKI is easily detected by a clinical assay. | Gabbard et al. Critical Care 2010 14 318 http content 14 4 318 CRITICAL CARE JOURNAL CLUB CRITIQUE L NGAL an emerging tool for predicting severity of AKI is easily detected by a clinical assay Wes Gabbard 1 Eric B Milbrandt2 and John A Kellum 3 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club edited by Eric B Milbrandt Expanded Abstract Citation Bennett M Dent CL Ma Q Dastrala S Grenier F Workman R Syed H Ali S Barasch J Devarajan P Urine NGAL predicts severity of acute kidney injury after cardiac surgery a prospective study. Clin J Am Soc Nephrol 2008 3 665-673 1 . Background The authors have previously shown that urine neutrophil gelatinase-associated lipocalin NGAL measured by a research ELISA is an early predictive biomarker of acute kidney injury AKI after cardiopulmonary bypass CPB . The availability of a standardized clinical platform for NGAL measurements could revolutionize renal diagnostics especially in intensive care situations. Methods Objective The first objective of the present study was to determine whether an NGAL immunoassay developed for a standardized clinical platform ARCHITECT analyzer Abbott Diagnostics correlates with the researchbased assay. The second objective was to determine the utility of the standardized NGAL immunoassay as a predictive biomarker of AKI after CPB in a large prospective cohort. Design Prospective cohort study Setting Children s hospital at a large US academic medical center. Subjects 196 children undergoing elective CPB for surgical correction or palliation of congenital heart lesions between January 2004 and June 2006. Intervention None. Outcomes The primary outcome variable was the development of AKI defined as a 50 or greater increase Corresponding author kellumja@ 3Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Full list of author information is .