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Báo cáo y học: "Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus: relationship to neuropsychiatric symptoms"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus: relationship to neuropsychiatric symptoms. | Available online http arthritis-research.eom content 10 4 R97 Research article Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus relationship to neuropsychiatric symptoms Annie George-Chandy1 2 Estelle Trysberg3 and Kristina Eriksson1 1 Department of Rheumatology and Inflammation Research Guldhedsgatan 10A 413 46 Gothenburg Sweden 2Department of Infection Immunology Statens Serum Institut Artillerivej 5 232 300 Copenhagen Denmark 3Rheumatogy Unit at Karolinska University Hospital Huddinge Hălsovăgen 141 141 52 Huddinge Sweden Corresponding author Annie George-Chandy annie.george.chandy@microbio.gu.se Received 2 Apr 2008 Revisions requested 29 Apr 2008 Revisions received 28 Jul 2008 Accepted 22 Aug 2008 Published 22 Aug 2008 Arthritis Research Therapy 2008 10 R97 doi 10.1186 ar2484 This article is online at http arthritis-research.com content 10 4 R97 2008 George-Chandy et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The tumour necrosis factor TNF family ligands BAFF B-cell activating factor of TNF family and APRIL a proliferation-inducing ligand are essential for B-cell survival and function. Elevated serum levels of BAFF and APRIL have been reported earlier in patients with systemic lupus erythematosus SLE . Since autoantibody formation in the central nervous system CNS is a distinct feature of neuropsychiatric SLE NPSLE we have investigated whether NPSLE is associated with an enhanced intrathecal production of APRIL and BAFF. Methods Levels of BAFF and APRIL in cerebrospinal fluid CSF and serum from healthy controls SLE patients without CNS involvement and patients with NPSLE were determined by enzyme-linked immunosorbent assay. Interleukin-6