Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo khoa học: " Stereotactic radiosurgery may contribute to overall survival for patients with recurrent head and neck carcinoma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Stereotactic radiosurgery may contribute to overall survival for patients with recurrent head and neck carcinoma. | Kawaguchi et al. Radiation Oncology 2010 5 51 http www.ro-journal.eom content 5 1 51 RADIATION ONCOLOGY RESEARCH Open Access Stereotactic radiosurgery may contribute to overall survival for patients with recurrent head and neck carcinoma Koji Kawaguchi 1 Kengo Sato2 Akihisa Horie1 Susumu Iketani3 Hiroyuki Yamada1 Yasunori Nakatani3 Junichi Sato1 and Yoshiki Hamada1 Abstract Background The aim of this study is to examine the effect of stereotactic radiosurgery SRS in the treatment of advanced recurrent lesions for head and neck carcinoma both with and without lymph node involvement. Methods Between April 2006 and July 2007 22 patients mean age 67 years with advanced recurrent head and neck carcinoma were treated with stereotactic radiosurgery. All of the patients except one had biopsy confirmed disease prior to stereotactic radiosurgery. Patients included 3 rT2 8 rT3 and 9 rT4 8 of the patients had lymph node metastases. Marginal SRS doses were 20-42 Gy delivered in two to five fractions. Starting one month after SRS all patients received S-1 oral chemotherapy for one year. Results At an overall median follow-up of 24 months range 4-39 months for the 14 locally recurrent patients without lymph node metastases 9 patients 64.3 had a complete response CR 1 patient 7.1 had a partial response PR 1 patient 7.1 had stable disease SD and 3 patients 21.4 had progressive disease PD . For the 8 patients with lymph node metastases 1 patient with a single retropharyngeal 12.5 had CR the remaining 7 patients 87.5 all progressed. Nine patients have died from their cancer. The overall actuarial 2-year survival for the patients with and without lymph node metastases is 12.5 and 78.6 respectively. Conclusions These results show the benefit of stereotactic radiosurgery salvage treatment for advanced recurrent lesions without lymph node metastases in previously irradiated head and neck cancer. Background The majority of head and neck region squamous cell carcinomas present at an .