tailieunhanh - Báo cáo khoa học: " Feasibility and early clinical assessment of flattening filter free (FFF) based stereotactic body radiotherapy (SBRT) treatments"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Feasibility and early clinical assessment of flattening filter free (FFF) based stereotactic body radiotherapy (SBRT) treatments. | Scorsetti et al. Radiation Oncology 2011 6 113 http content 6 1 113 RADIATION ONCOLOGY STUDY PROTOCOL Open Access Feasibility and early clinical assessment of flattening filter free FFF based stereotactic body radiotherapy SBRT treatments 1 1 r- - I- -1 2 2 1 Marta Scorsetti Filippo Alongi Simona Castiglioni Alessandro Clivio Antonella Fogliata Francesca Lobefalo 1 1 1 1 1 1 Pietro Mancosu Pierina Navarria Valentina Palumbo Chiara Pellegrini Sara Pentimalli Giacomo Reggiori Anna M Ascolese1 Antonella Roggio1 Stefano Arcangeli1 Angelo Tozzi1 Eugenio Vanetti2 and Luca Cozzi2 Abstract Purpose To test feasibility and safety of clinical usage of Flattening Filter Free FFF beams for delivering ablative stereotactic body radiation therapy SBRT doses to various tumor sites by means of Varian TrueBeam Varian Medical Systems . Methods and Materials Seventy patients were treated with SBRT and FFF 51 lesions were in the thorax 48 patients 10 in the liver 9 in isolated abdominal lymph node adrenal gland or pancreas. Doses ranged from 32 to 75 Gy depending on the anatomical site and the volume of the lesion to irradiate. Lung lesions were treated with cumulative doses of 32 or 48 Gy delivered in 4 consecutive fractions. The liver patients were treated in 3 fractions with total dose of 75 Gy. The isolated lymph nodes were irradiated in 6 fractions with doses of 45 Gy. The inclusion criteria were the presence of isolated node or few lymph nodes in the same lymph node region in absence of other active sites of cancer disease before the SBRT treatment. Results All 70 patients completed the treatment. The minimum follow-up was 3 months. Six cases of acute toxicities were recorded 2 Grade2 and 2 Grade3 in lung and 2 Grade2 in abdomen . No patient experienced acute toxicity greater than Grade3. No other types or grades of toxicities were observed at clinical evaluation visits. Conclusions This study showed that with respect to acute toxicity SBRT with FFF beams .