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báo cáo khoa học: "Diagnostic challenge for ovarian malignant melanoma in premenopausal women: Primary or metastatic?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Diagnostic challenge for ovarian malignant melanoma in premenopausal women: Primary or metastatic? | Sbitti et al. World Journal of Surgical Oncology 2011 9 65 http www.wjso.eom content 9 1 65 5 2 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Diagnostic challenge for ovarian malignant melanoma in premenopausal women Primary or metastatic 1.2 2 3 12 2 Yassir Sbitti 1 Zouhour Fadoukhair Habiba Kadiri Mohamed Oukabli Ismail Essaidi Saoussan Kharmoum Hind M rabti4 Abderrahmane Albouzidi3 Mohammed Ichou1 and Hassan Errihani2 Abstract Background In the ovary metastatic malignant melanoma may be confused with primary malignant melanoma and presents a diagnosis challenge. Most cases are associated with disseminated diseases and poor prognosis. We present this case report of a metastatic ovarian malignant melanoma simulating primary ovarian cancer. Case report A 45-year-old premenopausal woman was incidentally found to have an abdominal mass 3 years after removal of a cutaneous melanoma lesion. Ultrasound and CT scan revealed left two solid masses which were found to be an ovarian tumor at laparotomy. Left oophorectomy was performed. Histopathology and immunohistochemistry showed melanoma metastasis to the ovary. Nine months later the patient developed epilepsy and confusion. Magnetic Resonance Imaging showed unique Wright frontal lobe lesion. She underwent stereotactic radio surgery and dacarbazine monotherapy. For months later the patient is died from disseminate disease progression. Conclusion Ovarian metastasis is an unusual presentation of cutaneous melanoma and the prognosis was dismal. As illustrated by this case report a differential diagnosis of a metastatic malignant melanoma must be considered. Keywords melanoma ovarian neoplasm secondary differential diagnosis Introduction The ovary is a frequent site of secondary spread from extra-ovarian malignancies. Approximately 6-7 of the patients presenting with suspected ovarian neoplasm will prove to suffer from metastatic disease to the ovary 1 . Ovarian involvement by metastatic malignant melanoma is .