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báo cáo khoa học: "Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients | Ravishankaran and Karunanithi World Journal of Surgical Oncology 2011 9 18 http www.wjso.eom content 9 1 18 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients Praveen Ravishankaran1 R Karunanithi2 Abstract Background Breast cancer is a disease that continues to plague females during their entire lifetime. IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the disease. The primary objective of this study was to determine the preoperative serum levels of IL-6 and CRP in breast carcinoma and to correlate them with the staging of the disease and the prognosis. Methods 59 female patients admitted for breast cancer were identified for the study and were subjected to thorough evaluation. Serum levels of IL-6 were assessed via Enzyme-Linked Immuno-Sorbent Assay ELISA and CRP was measured via immunoturbidimetry. Histological findings included tumour size lymph node LN metastasis and tumour staging. Relevant investigations were made to find out the presence of distant metastasis. Statistical analysis of the data was then processed. Results Increases in cancer invasion and staging are generally associated with increases in preoperative serum IL-6 levels. IL-6 and CRP levels correlated with LN metastasis P 0.001 P 0.001 and TNM stage P 0.001 P 0.001 . Tumour invasion and the presence of distant metastasis is associated with higher IL-6 levels P 0.001 P 0.009 . When we established the cutoff value for IL-6 level 20.55 pg dl by ROC curve we noted a significant difference in overall survival OS P 0.008 . However CRP evidenced no significance with regard to patient s OS levels. Serum IL-6 levels were correlated positively with CRP levels r2 0.579 P 0.01 Conclusion Serum levels of IL-6 correlates well with the extent of tumor invasion LN metastasis distant metastasis and