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báo cáo hóa học: " Lung responses to secondary endotoxin challenge in rats exposed to pig barn air"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài:Lung responses to secondary endotoxin challenge in rats exposed to pig barn air | Journal of Occupational Medicine and Toxicology BioMed Central Research Lung responses to secondary endotoxin challenge in rats exposed to pig barn air Chandrashekhar Charavaryamath1 2 Taryn Keet2 Gurpreet K Aulakh2 Hugh GG Townsend3 and Baljit Singh 1 2 Address immunology and Infectious Disease Research Group University of Saskatchewan Saskatoon SK S7N 5B4 Canada 2Department of Veterinary Biomedical Sciences University of Saskatchewan Saskatoon SK S7N 5B4 Canada and 3Department of Large Animal Clinical Sciences University of Saskatchewan Saskatoon SK S7N 5B4 Canada Email Chandrashekhar Charavaryamath - c.chandru@usask.ca Taryn Keet - tlk113@mail.usask.ca Gurpreet K Aulakh - gka240@mail.usask.ca Hugh GG Townsend - hugh.townsend@usask.ca Baljit Singh - baljit.singh@usask.ca Corresponding author Open Access Published 30 October 2008 Received 29 August 2008 Journal of Occupational Medicine and Toxicology 2008 3 24 doi 10.1186 1745-6673-3-24 Accepted 30 October 2008 This article is available from http www.occup-med.com content 3 1 24 2008 Charavaryamath et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Swine barn air contains endotoxin and many other noxious agents. Single or multiple exposures to pig barn air induces lung inflammation and loss of lung function. However we do not know the effect of exposure to pig barn air on inflammatory response in the lungs following a secondary infection. Therefore we tested a hypothesis that single or multiple exposures to barn air will result in exaggerated lung inflammation in response to a secondary insult with Escherichia coli LPS E. coli LPS . Methods We exposed .