tailieunhanh - Báo cáo hóa học: " Lung inflammation following a single exposure to swine barn air"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Lung inflammation following a single exposure to swine barn air | Journal of Occupational Medicine and Toxicology BioMed Central Research Lung inflammation following a single exposure to swine barn air Lakshman Nihal Angunna Gamage1 Chandrashekhar Charavaryamath1 Trisha Lee Swift2 and Baljit Singh 1 3 Address Department of Veterinary Biomedical Sciences University of Saskatchewan Saskatoon Canada 2University of Alberta Edmonton AB Canada and 3Immunology Research Group University of Saskatchewan Saskatoon Canada Email Lakshman Nihal Angunna Gamage - lag153@ Chandrashekhar Charavaryamath - Trisha Lee Swift - tswift@ Baljit Singh - Corresponding author Open Access Published 18 December 2007 Received 29 July 2007 . . . _ Accepted 18 December 2007 Journal of Occupational Medicine and Toxicology 2007 2 18 doi 1745-6673-2-18 This article is available from http content 2 1 18 2007 Gamage et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Exposure to swine barn air is an occupational hazard. Barn workers following an eight-hour work shift develop many signs of lung dysfunction including lung inflammation. However the in situ cellular and molecular mechanisms responsible for lung dysfunction induced following exposure to the barn air remain largely unknown. Specifically the recruitment and role of pulmonary intravascular monocytes macrophages PIMMs which increase host susceptibility for acute lung inflammation remain unknown in barn air induced lung inflammation. We hypothesized that barn exposure induces recruitment of PIMMs and increases susceptibility for acute lung inflammation with a secondary challenge. Methods Sprague-Dawley rats were exposed either to the barn or ambient air for