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báo cáo hóa học: " The microglial "activation" continuum: from innate to adaptive responses"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The microglial "activation" continuum: from innate to adaptive responses | Journal of Neuroinflammation BioMed Central Review Open Access The microglial activation continuum from innate to adaptive responses Terrence Town 1 2 Veljko Nikolic2 and Jun Tan 2 Address 1Section of Immunobiology Yale University School of Medicine 300 Cedar St. New Haven CT 06520-8011 USA and 2Neuroimmunology Laboratory Silver Child Development Center Department of Psychiatry and Behavioral Medicine University of South Florida 3515 E. Fletcher Ave. Tampa FL 33613 UsA Email Terrence Town - terrence.town@yale.edu Veljko Nikolic - vnikolic@smtp.hsc.usf.edu Jun Tan - jtan@hsc.usf.edu Corresponding authors Published 31 October 2005 Received 24 October 2005 Journal ofNeuroinflammation 2005 2 24 doi l0.ll86 l742-2094-2-24 Accepted 31 October 2005 This article is available from http www.jneuroinflammation.com content 2 1 24 2005 Town et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Microglia are innate immune cells of myeloid origin that take up residence in the central nervous system CNS during embryogenesis. While classically regarded as macrophage-like cells it is becoming increasingly clear that reactive microglia play more diverse roles in the CNS. Microglial activation is often used to refer to a single phenotype however in this review we consider that a continuum of microglial activation exists with phagocytic response innate activation at one end and antigen presenting cell function adaptive activation at the other. Where activated microglia fall in this spectrum seems to be highly dependent on the type of stimulation provided. We begin by addressing the classical roles of peripheral innate immune cells including macrophages and dendritic cells which seem to define the edges of this continuum. We then .