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Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 2)

Table 114-1 Examples of Microbial Ligand-Receptor Interactions Microorganism Type of Microbial Ligand Host Receptor Viral Pathogens Influenza virus Hemagglutinin Sialic acid Measles virus Vaccine strain Hemagglutinin CD46/moesin Wild-type strains Hemagglutinin Signaling lymphocytic activation molecule (SLAM) Human herpesvirus type 6 ? CD46 Herpes simplex virus Glycoprotein C Heparan sulfate HIV Surface glycoprotein CD4 and chemokine receptors CXCR4) (CCR5 and Epstein-Barr virus Envelope protein CD21 (=CR2) Adenovirus Fiber protein Coxsackie-adenovirus receptor (CAR) Coxsackievirus Viral coat proteins CAR and major class I histocompatibility antigens Bacterial Pathogens Neisseria spp. Pili Membrane protein (CD46) cofactor Pseudomonas aeruginosa Pili and flagella Asialo-GM1 Lipopolysaccharide Cystic fibrosis transmembrane conductance regulator (CFTR) . | Chapter 114. Molecular Mechanisms of Microbial Pathogenesis Part 2 Table 114-1 Examples of Microbial Ligand-Receptor Interactions Microorganism Type of Microbial Ligand Host Receptor Viral Pathogens Influenza virus Hemagglutinin Sialic acid Measles virus Vaccine strain Hemagglutinin CD46 moesin Wild-type strains Hemagglutinin Signaling lymphocytic activation molecule SLAM Human herpesvirus type 6 CD46 Herpes simplex virus Glycoprotein C Heparan sulfate HIV Surface glycoprotein CD4 and chemokine receptors CCR5 and CXCR4 Epstein-Barr virus Envelope protein CD21 CR2 Adenovirus Fiber protein Coxsackie-adenovirus receptor CAR Coxsackievirus Viral coat proteins CAR and major histocompatibility class I antigens Bacterial Pathogens Neisseria spp. Pili Membrane cofactor protein CD46 Pseudomonas aeruginosa Pili and flagella Lipopolysaccharide Asialo-GMi Cystic fibrosis transmembrane conductance regulator CFTR Escherichia coli Pili Ceramides mannose and digalactosyl residues Streptococcus pyogenes Hyaluronic acid capsule CD44 Yersinia spp. Invasin accessory Pi .