tailieunhanh - Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 7)

Encounters with Phagocytes Phagocytosis and Inflammation Phagocytosis of microbes is a major innate host defense that limits the growth and spread of pathogens. Phagocytes appear rapidly at sites of infection in conjunction with the initiation of inflammation. Ingestion of microbes by both tissue-fixed macrophages and migrating phagocytes probably accounts for the limited ability of most microbial agents to cause disease. A family of related molecules called collectins, soluble defense collagens, or pattern-recognition molecules are found in blood (mannose-binding lectins), in lung (surfactant proteins A and D), and most likely in other tissues as well and bind to carbohydrates on microbial. | Chapter 114. Molecular Mechanisms of Microbial Pathogenesis Part 7 Encounters with Phagocytes Phagocytosis and Inflammation Phagocytosis of microbes is a major innate host defense that limits the growth and spread of pathogens. Phagocytes appear rapidly at sites of infection in conjunction with the initiation of inflammation. Ingestion of microbes by both tissue-fixed macrophages and migrating phagocytes probably accounts for the limited ability of most microbial agents to cause disease. A family of related molecules called collectins soluble defense collagens or pattern-recognition molecules are found in blood mannose-binding lectins in lung surfactant proteins A and D and most likely in other tissues as well and bind to carbohydrates on microbial surfaces to promote phagocyte clearance. Bacterial pathogens seem to be ingested principally by polymorphonuclear neutrophils PMNs while eosinophils are frequently found at sites of infection with protozoan or multicellular parasites. Successful pathogens by definition must avoid being cleared by professional phagocytes. One of several antiphagocytic strategies employed by bacteria and by the fungal pathogen Cryptococcus neoformans is to elaborate large-molecular-weight surface polysaccharide antigens often in the form of a capsule that coats the cell surface. Most pathogenic bacteria produce such antiphagocytic capsules. On occasion proteins or polypeptides form capsule-like coatings on organisms such as Bacillus anthracis. As activation of local phagocytes in tissues is a key step in initiating inflammation and migration of additional phagocytes into infected sites much attention has been paid to microbial factors that initiate inflammation. Encounters with phagocytes are governed largely by the structure of the microbial constituents that elicit inflammation and detailed knowledge of these structures for bacterial pathogens has contributed greatly to our understanding of molecular mechanisms of microbial pathogenesis

• Y học thường thức
• Molecular Mechanisms
• Microbial Pathogenesis
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu học ngành y
• Harrisons Internal Medicine
• QTL and molecular markers
• Molecular markers
• Drought tolerance in rice
• Stress on phenotypic traits in rice
• health
• care
• primary
• report
• Meiosis
• Molecular
• Mechanisms
• Cytogenetic Diversity
• Andrew Swan
• environmental
• Viral Genomes
• Molecular Structure
• Diversity
• Gene
• Host Virus Interactions
• Maria Laura Garcia and Víctor Romanowski
• Reveal pharmacological targets
• Curcumol against interstitial cystitis
• Interstitial cystitis
• Protein protein interaction
• BMC Bioinformatics
• Estimating coherence
• Human disease
• Therapeutic intervention
• Chronic obstructive pulmonary disease
• Chronic disorders
• Disease gene
• Molecular approach towards defence mechanisms
• Defence against pathogens and pest
• Cellular adaptations
• Involve numerous physiological
• Pathogenic microorganisms
• Luận án Tiến sĩ
• Luận án Tiến sĩ Máy tính
• Molecular mechanisms involved
• The regulatory role of A20 gene
• Controlling dendritic cell physiology
• Genome Biology
• Integrative genomics
• Multi omics
• Conditional association analysis
• BMC Molecular and Cell Biology
• Soluble receptor
• Synovial fibroblast
• Inflammatory response
• Rheumatoid arthritis
• Cross talk
• Transcriptional mechanisms
• Post transcriptional mechanisms
• Plant Biology
• Rhizosphere interaction
• Nitrogen uptake
• Nitrogen transfer
• Differentially expressed proteins
• Neuroprotective Effect
• Cerebral Ischemia
• Brain Regeneration
• Spontaneous Events
• Stem Cells Therapy
• Intraepithelial neoplasia
• human body
• precursor lesions
• genetic mechanisms
• molecular diagnostics
• Heart rate
• Rhythm molecular basis pharmacological modulation
• Basis pharmacological modulation
• Normal cardiac rhythm
• Pacemaker activity
• Cardiac development
• Mechanisms of acquired arrhythmia
• Mechanisms of inherited arrhythmia
• Role of specific channels and transporters in arrhythmia
• Drugs and cardiac arrhythmia