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Negative selection pressure against premature protein truncation is reduced by both alternative splicing and diploidy

reviews Address: Molecular Biology Institute, Center for Genomics and Proteomics, Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095-1570, USA. Correspondence: Christopher Lee. E-mail: leec@mbi.ucla.edu reports Posted: 29 April 2004 Genome Biology 2004, 5:P12 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/6/P12 © 2004 BioMed Central Ltd Received: 27 April 2004 This is the first version of this article to be made available publicly. deposited research refereed research .deposited research AS A SERVICE TO THE RESEARCH COMMUNITY, GENOME BIOLOGY PROVIDES A 'PREPRINT' DEPOSITORY TO WHICH. | This information has not been peer-reviewed. Responsibility for the findings rests solely with the author s . Deposited research article Negative selection pressure against premature protein truncation is reduced by both alternative splicing and diploidy Yi Xing and Christopher Lee Address Molecular Biology Institute Center for Genomics and Proteomics Department of Chemistry and Biochemistry University of California Los Angeles CA 90095-1570 USA. Correspondence Christopher Lee. E-mail leec@mbi.ucla.edu Posted 29 April 2004 Genome Biology 2004 5 P12 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2004 5 6 P12 2004 BioMed Central Ltd Received 27 April 2004 This is the first version of this article to be made available publicly. .deposited research AS A SERVICE TO THE RESEARCH COMMUNITY GENOME BIOLOGY PROVIDES A PREPRINT DEPOSITORY TO WHICH ANY ORIGINAL RESEARCH CAN BE SUBMITTED AND WHICH ALL INDIVIDUALS CAN ACCESS FREE OF CHARGE. ANY ARTICLE CAN BE SUBMITTED BY AUTHORS WHO HAVE SOLE RESPONSIBILITY FOR Ho jBj THE ARTICLE S CONTENT. THE ONLY SCREENING IS TO ENSURE RELEVANCE OF THE PREPRINT TO GENOME BIOLOGY S SCOPE AND TO AVOID ABUSIVE LIBELLOUS OR INDECENT ARTICLES. ARTICLES IN THIS SECTION OF THE JOURNAL HAVE NOT BEEN PEER-REVIEWED. EACH PREPRINT HAS A PERMANENT URL BY WHICH IT CAN BE CITED. RESEARCH SUBMITTED TO THE PREPRINT DEPOSITORY MAY BE SIMULTANEOUSLY OR SUBSEQUENTLY SUBMITTED TO GENOME BIOLOGY OR ANY OTHER PUBLICATION FOR PEER REVIEW THE ONLY REQUIREMENT IS AN EXPLICIT CITATION OF AND LINK TO THE PREPRINT IN ANY VERSION OF THE ARTICLE THAT IS EVENTUALLY PUBLISHED. IF POSSIBLE GENOME BIOLOGY WILL PROVIDE A RECIPROCAL LINK FROM THE PREPRINT TO THE PUBLISHED ARTICLE. Genome Biology 2004 5 P12 Negative Selection Pressure Against Premature Protein Truncation Is Reduced by both Alternative Splicing and Diploidy Yi Xing Christopher Lee Molecular Biology Institute Center for Genomics and Proteomics Dept. of