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Báo cáo khoa học: "Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation | J. Vet. Set. 2006 7 4 375-379 JOURNAL OF Veterinary Science Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation Jae-il Lee1 Hwa-Young Son2 Myung-cheol Kim1 Laboratory of Veterinary Surgery and laboratory of Veterinary Pathology College of Veterinary Medicine Chungnam National University Daejeon 305-764 Korea This study examined the effects of ascorbic acid on the attenuation of an ischemia-reperfusion IZR injury after a canine renal transplantation. Eight beagle dogs were subjected to a renal auto-transplantation followed by the administration of ascorbic acid treatment group and the same amount of vehicle physiological saline control group . Blood samples were collected from these dogs to perform the kidney function tests and the invasive blood pressure was measured in the renal artery at pre- and post- anastomosis. The antioxidant enzymes of level 72 h after the transplant were measured. The kidneys were taken for a histopathology evaluation at day 21. The kidney function tests showed a significant difference between the control and treatment group. The invasive blood pressure in the renal artery was similar in the groups. The activity of the antioxidant enzymes in the blood plasma was significant lower in the control group than in the treatment group. The histopathology findings revealed the treatment group to have less damage than the control group. The results of this study suggest that ascorbic acid alone might play a role in attenuating I R injury and assist in the recovery of the renal function in a renal transplantation model. Key words antioxidant ascorbic acid canine renal transplantation Introduction Kidney transplantation is the ideal treatment for chronic renal failure and various end-stage renal diseases 4 13 20 . The viability of the transplanted organ depends its ability to tolerate cold and warm ischemia and reperfusion during surgery 6 10 . Ischemia-reperfusion injury is a major cause of renal failure .