tailieunhanh - Báo cáo y học: "Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1)"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1). | Available online http content 8 1 R17 Open Access Research article Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 STAT-1 Marion Huckel1 Uta Schurigt1 Andreas H Wagner2 Renate Stockigt1 Peter K Petrow1 Klaus Thoss1 Mieczyslaw Gajda1 Steffen Henzgen3 Markus Hecker2 and Rolf Brauer1 institute of Pathology Friedrich Schiller University Jena Germany institute of Physiology and Pathophysiology Ruprecht Karls University Heidelberg Germany institute of Pathology Dietrich Bonhoeffer Clinical Centre Neubrandenburg Germany Corresponding author Rolf Brauer Received 26 Apr 2005 Revisions requested 20 May 2005 Revisions received 27 Oct 2005 Accepted 21 Nov 2005 Published 30 Dec 2005 Arthritis Research Therapy 2006 8 R17 doi ar1 869 This article is online at http content 8 1 R1 7 2005 Huckel et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The transcription factor STAT-1 signal transducer and activator of transcription-1 plays a pivotal role in the expression of inflammatory gene products involved in the pathogenesis of arthritis such as various cytokines and the CD40 CD40 ligand CD40 CD40L receptor-ligand dyad. The therapeutic efficacy of a synthetic decoy oligodeoxynucleotide ODN binding and neutralizing STAT-1 was tested in murine antigen-induced arthritis AIA as a model for human rheumatoid arthritis RA . The STAT-1 decoy ODN was injected intra-articularly in methylated bovine serum albumin mBSA -immunized mice 4 h before arthritis induction. Arthritis was evaluated by joint swelling measurement and histological evaluation and .

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