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Báo cáo khoa hoc:" Alternative models for QTL detection in livestock. I. General introduction"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Alternative models for QTL detection in livestock. I. General introduction | Genet. Sei. Evol. 31 1999 213-224 Inra Elsevier Paris 213 Original article Alternative models for QTL detection in livestock. I. General introduction Jean-Michel Elsena Brigitte Manginb Bruno Goffinetb Didier Boichardc Pascale Le Royc a Station d amelioration génétique des animaux Institut national de la recherche agronomique BP27 31326 Auzeville France b Laboratoire de biométrie et d intelligence artificielle Institut national de la recherche agronomique BP27 31326 Auzeville France c Station de génétique quantitative et appliquée Institut national de la recherche agronomique 78352 Jouy-en-Josas France Received 20 November 1998 accepted 26 March 1999 Abstract - In a series of papers alternative models for QTL detection in livestock are proposed and their properties evaluated using simulations. This first paper describes the basic model used applied to independent half-sib families with marker phenotypes measured for a two or three generation pedigree and quantitative trait phenotypes measured only for the last generation. Hypotheses are given and the formulae for calculating the likelihood axe fully described. Different alternatives to this basic model were studied including variation in the performance modelling and consideration of full-sib families. Their main features are discussed here and their influence on the result illustrated by means of a numerical example. Inra Elsevier Paris QTL detection maximum likelihood Resume Modèles alternatifs pour la detection de QTL dans les populations animates. I. Introduction générale. Dans une série d articles scientifiques des modèles alternatifs pour la detection de QTLs chez les animaux de ferme sont proposes et leurs propriétés sont évaluées par simulation. Ce premier article décrit le modèle de base utilise qui concerne des families indépendantes de demi-germains de père avec des phenotypes marqueurs mesurés sur deux OU trois generations et des phenotypes quantitatifs mesurés seulement sur la dernière generation. Les