tailieunhanh - Báo cáo khoa học: "Alternative protocol to initiate high-frequency oscillatory ventilation: an experimental study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Alternative protocol to initiate high-frequency oscillatory ventilation: an experimental study. | Available online http content 10 5 R138 Research Alternative protocol to initiate high-frequency oscillatory ventilation an experimental study Jens Karmrodt Matthias David Shying Yuan and Klaus Markstaller Department of Anesthesiology Johannes Gutenberg-University LangenbeckstraBe 1 D-55101 Mainz Germany Corresponding author Jens Karmrodt karmrodt@ Received 15 May 2006 Revisions requested 13 Jun 2006 Revisions received 4 Sep 2006 Accepted 25 Sep 2006 Published 25 Sep 2006 Critical Care 2006 10 R138 doi cc5052 This article is online at http content 10 5 R138 2006 Karmrodt et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The objective was to study the effects of a novel lung volume optimization procedure LVOP using high-frequency oscillatory ventilation HFOV upon gas exchange the transpulmonary pressure TPP and hemodynamics in a porcine model of surfactant depletion. Methods With institutional review board approval the hemodynamics blood gas analysis TPP and pulmonary shunt fraction were obtained in six anesthetized pigs before and after saline lung lavage. Measurements were acquired during pressure-controlled ventilation PCV prior to and after lung damage and during a LVOP with HFOV. The LVOP comprised a recruitment maneuver with a continuous distending pressure CDP of 45 mbar for minutes and a stepwise decrease of the CDP 5 mbar every 5 minute from 45 to 20 mbar. The TPP level was identified during the decrease in CDP which assured a change of the PaO2 F O2 ratio 25 compared with maximum lung recruitment at CDP of 45 mbar CDP45 . Data are presented as the median 25th 75th percentile differences between measurements are determined by .