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Báo cáo sinh học: " Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: An experimental murine model"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: An experimental murine model | Virology Journal BioMed Central Research Open Access Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background An experimental murine model Susana Chavez-Bueno1 Asuncion Mejias1 Ana M Gomez2 Kurt D Olsen1 Ana M Ríos1 Mónica Fonseca-Aten1 Octavio Ramilo1 and Hasan S Jafri 1 Address 1Division of Pediatric Infectious Diseases Department of Pediatrics The University of Texas Southwestern Medical Center at Dallas and Children s Medical Center Dallas Dallas Texas USA and 2Department of Pathology The University of Texas Southwestern Medical Center at Dallas and Children s Medical Center Dallas Dallas Texas USA Email Susana Chávez-Bueno - susana.chavez-bueno@utsouthwestern.edu Asunción Mejías - asuncion.mejias@utsouthwestern.edu Ana M Gómez - ana.gomez@utsouthwestern.edu Kurt D Olsen - kurt.olsen@utsouthwestern.edu Ana M Ríos - anamariarios@msn.com Mónica Fonseca-Aten - monica.fonseca-aten@utsouthwestern.edu Octavio Ramilo - octavio.ramilo@utsouthwestern.edu Hasan S Jafri - hasan.jafri@utsouthwestern.edu Corresponding author Published 25 May 2005 Received 26 April 2005 Accepted 25 May 2005 Virology Journal 2005 2 46 doi l0.ll86 l 743-422X-2-46 This article is available from http www.virologyj.cOm content 2 1 46 2005 Chávez-Bueno et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Respiratory syncytial virus RSV is the leading respiratory viral pathogen in young children worldwide. RSV disease is associated with acute airway obstruction AO long-term airway hyperresponsiveness AHR and chronic lung inflammation. Using two different mouse strains this study was designed to determine whether RSV disease patterns are host-dependent. C57BL 6 and BALB c mice were .