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Báo cáo sinh học: " Identification of a truncated nucleoprotein in avian metapneumovirus-infected cells encoded by a second AUG, in-frame to the full-length gene"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Identification of a truncated nucleoprotein in avian metapneumovirus-infected cells encoded by a second AUG, in-frame to the full-length gene | Virology Journal BioMed Central Research Open Access Identification of a truncated nucleoprotein in avian metapneumovirus-infected cells encoded by a second AUG in-frame to the full-length gene Rene Alvarez1 2 and Bruce S Seal 1 3 Address Southeast Poultry Research Laboratory Agricultural Research Service U.S. Department of Agriculture Athens GA 30605 USA 2Present address Department of Infectious Diseases College of Veterinary Medicine University of Georgia Athens GA 30605 USA and 3Poultry Microbiological Safety Research Unit ARS USDA 950 College Station Rd. Athens GA 30605 USA Email Rene Alvarez - ralvarez@vet.uga.edu Bruce S Seal - bseal@saa.ars.usda.gov Corresponding author Published 12 April 2005 Received 04 April 2005 Accepted 12 April 2005 Virology Journal 2005 2 31 doi l0.ll86 l 743-422X-2-31 This article is available from http www.virologyj.cOm content 2 1 31 2005 Alvarez and Seal licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Avian metapneumoviruses aMPV cause an upper respiratory disease with low mortality but high morbidity primarily in commercial turkeys. There are three types of aMPV A B C of which the C type is found only in the United States. Viruses related to aMPV include human bovine ovine and caprine respiratory syncytial viruses and pneumonia virus of mice as well as the recently identified human metapneumovirus hMPV . The aMPV and hMPV have become the type viruses of a new genus within the Metapneumovirus. The aMPV nucleoprotein N amino acid sequences of serotypes A B and C were aligned for comparative analysis. Based on predicted antigenicity of consensus protein sequences five aMPV-specific N peptides were synthesized for development of peptide-antigens and antisera. Results The .