tailieunhanh - Báo cáo sinh học: "Identification of common fragile sites in chromosomes of 2 species of bat"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Identification of common fragile sites in chromosomes of 2 species of bat | u a I lAI Genet Sei Evol 1994 26 81-89 Elsevier INRA D flis . c . fi F . .i- 81 Original article Identification of common fragile sites in chromosomes of 2 species of bat Chiroptera Mammalia E Morielle-Versute1 M Varella-Garcia2 1 Department of Zoology 2 Department of Biology Institute of Biosciences UNESP PO Box 136 São José do Rio Preto 1505ị000 SP Brazil Received 14 October 1992 accepted 2 December 1993 Summary - In the karyotypes of the bat species Molossus ater and M molossus spontaneous and bromodeoxyuridine BrdU - or aphidicolin APC -sensitive fragile sites were located. Four chromosome regions harbored APC-sensitive fragile sites lq9 and 8q4 in both M ater and M molossus 3q3 in M ater and lp7 in M molossus. The fragile sites in lq9 and 8q4 were also observed without induction in M molossus. BrdU-sensitive fragile sites were not detected. Despite observations in several other species the fragile sites detected in Molossus are not coincident with the breakpoints involved in the chromosome rearrangements occurring in the evolution of 7 species of the Molossidae family. fragile site chromosome bat bromodeoxyuridine induction aphidicolin induction Resume Identification de sites chromosomiques fragiles communs à 2 espèces de chauve-souris. L analyse de la fragilite chromosomique spontanée OU induite par bromodéoxyuridine BrdU et aphidicholine APC réalisée sur le caryotype de 2 espèces de chauve-souris Molossus ater et M molossus a permis d identifier 4 sites fragiles induits par APC lq9 et 8q4 chez M ater et M molossus 3q3 chez M ater et lp7 chez M molossus. Les sites fragiles en lq9 et 8q4 ont aussi été observes chez M molossus sans induction. Les sites fragiles repérés dans ces espèces ne coincident pas avec les points de cassure impliqués dans les rearrangements chromosomiques qui ont eu lieu au cours de revolution de 7 espèces de la famille des Molossidae. site fragile chromosome chauve-souris induction par bromodéoxyuridine induction par aphidicholine 82 E .