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Báo cáo khoa học: "Influence of gestational age at exposure on the prenatal effects of gamma-radiation"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Influence of gestational age at exposure on the prenatal effects of gamma-radiation | J. Vet. Sci. 2001 2 1 37-42 JOURNAL OF Veterinary Science Influence of gestational age at exposure on the prenatal effects of gamma-radiation Sung-ho Kim Se-ra Kim Yun-sil Lee1 Tae-hwan Kim1 Sung-kee Jo2 and Cha-soo Lee3 Department of Anatomy College of Veterinary Medicine Chonnam National University Kwangju 500-757 Korea 1 Korea Cancer Center Hospital Seoul 139-240 Korea 2Food Irradiation Team KAERI Taejeon 305-353 Korea Department of Pathology College of Veterinary Medicine Kyungpook National University Taegu 702-701 Korea The objective of this investigation was to evaluate the influence of gestational age at exposure on the prenatal effects of gamma-radiation. Pregnant ICR mice were exposed to a single dose of 2.0 Gy gamma-radiation at a gestational 2.5 to 15.5 days post-coitus p.c. . The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality growth retardation change in head size and any other morphological abnormalities. The only demonstrable effect of irradiation during the preimplantation period was an increase in prenatal mortality. Resorptions were maximal on post-exposure day 2.5 after conception. The pre-implantation irradiated embryos which survived did not show any major fetal abnormalities. Small head growth retardation cleft palate dilatation of the cerebral ventricle dilatation of the renal pelvis and abnormalities of the extremities and tail were prominent after exposure during the organogenesis period especially on day 11.5 of gestation. Our results indicate that the late period of organogenesis in the mouse is a particularly sensitive phase in terms of the development of the brain skull and extremities. Key words radiation malformation mouse gestational age Introduction Irradiation of mammalian embryos can produce a spectrum of morphological changes ranging from temporary stunting of growth to severe organ defects and death 2 . During the period of major organogenesis mammalian embryos are highly susceptible to