tailieunhanh - Báo cáo khoa học: "Influence of insulin on glucose metabolism and energy expenditure in septic patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Influence of insulin on glucose metabolism and energy expenditure in septic patients. | Available online http content 8 4 R213 Research Influence of insulin on glucose metabolism and energy expenditure in septic patients Zdenek Rusavy1 Vladimir Sramek2 Silvie Lacigova3 Ivan Novak4 Pavel Tesinsky5 and Ian A Macdonald6 Open Access 1Head Metabolic Group in Plzen Department of Medicine I Charles University Hospital Plzen Czech Republic 2Doctor Intensive Care Medicine in Brno Department of Anestesiology and Intensive Care University Hospital Brno Czech Republic 3Doctor Diabetology and Nutrition Unit in Plzen Department of Medicine I Charles University Hospital Plzen Czech Republic 4Head Intensive Care Unit in Plzen Department of Medicine I Charles University Hospital Plzen Czech Republic 5Doctor Nutrition Unit Department of Medicine I Charles University Hospital Plzen Czech Republic 6Professor and Dean of Medical School Department of Physiology and Pharmacology QMC Nottingham UK Corresponding author Zdenek Rusavy rusavy@ Received 05 November 2003 Revisions requested 2 February 2004 Revisions received 5 April 2004 Accepted 20 April 2004 Published 26 May 2004 Critical Care 2004 8 R213-R220 DOI cc2868 This article is online at http content 8 4 R213 2004 Rusavy et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Introduction It is recognized that administration of insulin with glucose decreases catabolic response in sepsis. The aim of the present study was to compare the effects of two levels of insulinaemia on glucose metabolism and energy expenditure in septic patients and volunteers. Methods Glucose uptake oxidation and storage and energy expenditure were measured using indirect calorimetry in 20 stable septic patients and 10 volunteers in a two-step hyperinsulinaemic serum insulin levels 250 and 1250 mIU l euglycaemic blood .