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Báo cáo sinh học: "Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation | Lo lacono et al. Journal of Translational Medicine 2011 9 100 http www.translational-medicine.eom content 9 1 100 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation Marco Lo lacono Valentina Monica Silvia Saviozzi Paolo Ceppi Enrico Bracco Mauro Papotti and Giorgio V Scagliotti Abstract Background Aurora kinase A AURKA is a member of serine threonine kinase family. Several kinases belonging to this family are activated in the G2 M phase of the cell cycle being involved in mitotic chromosomal segregation. AURKA overexpression is significantly associated with neoplastic transformation in several tumors and deregulated Aurora Kinases expression leads to chromosome instability thus contributing to cancer progression. The purpose of the present study was to investigate the expression of AURKA in non small cell lung cancer NSCLC specimens and to correlate its mRNA or protein expression with patients clinico-pathological features. Materials and methods Quantitative real-time PCR and immunohistochemistry analysis on matched cancer and corresponding normal tissues from surgically resected non-small cell lung cancers NSCLC have been performed aiming to explore the expression levels of AURKA gene. Results AURKA expression was significantly up-modulated in tumor samples compared to matched lung tissue p 0.01 mean log2 FC 1.5 . Moreover AURKA was principally up-modulated in moderately and poorly differentiated lung cancers p 0.01 as well as in squamous and adenocarcinomas compared to the non-invasive bronchioloalveolar histotype p 0.029 . No correlation with survival was observed. Conclusion These results indicate that in NSCLC AURKA over-expression is restricted to specific subtypes and poorly differentiated tumors. Background Aurora kinase A AURIIA is a member of serine threo-nine kinase family homologous to both the Drosophila aurora and Saccharomyces .