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Báo cáo sinh học: " Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals - the Swiss HIV Cohort Study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals - the Swiss HIV Cohort Study | Fehr et al. Journal of Translational Medicine 2011 9 14 http www.translational-medicine.eom content 9 1 14 TRANSLATIONAL MEDICINE RESEARCH Open Access Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals - the Swiss HIV Cohort Study I s u . c L. u- 1 f I u- s I D rd I S r r 2 f c A rl I z I I ỉ 13 4 c r-s S Ì I r I_I M W 3 I_I s V r- I_I I_I I rr 1 4 f l f z r 1 S A l5 II im D Av l6 Jan Fehr Tracy R Glass Severine Louvel Francois Hamy Hans H Hirsch ViKtor von wyi Jurg Boni 7 8 9 10 11 12 Sabine Yerly Philippe Burgisser Matthias Cavassini Christoph A Fux Bernard Hirschel Pietro Vernazza 13 14 5 1 2 Gladys Martinetti Enos Bernasconi Huldrych F Gunthard Manuel Battegay Heiner C Bucher Thomas KlimKait4 the Swiss HIV Cohort Study Abstract Background Replicative phenotypic HIV resistance testing rPRT uses recombinant infectious virus to measure viral replication in the presence of antiretroviral drugs. Due to its high sensitivity of detection of viral minorities and its dissecting power for complex viral resistance patterns and mixed virus populations rPRT might help to improve HIV resistance diagnostics particularly for patients with multiple drug failures. The aim was to investigate whether the addition of rPRT to genotypic resistance testing GRT compared to GRT alone is beneficial for obtaining a virological response in heavily pre-treated HIV-infected patients. Methods Patients with resistance tests between 2002 and 2006 were followed within the Swiss HIV Cohort Study SHCS . We assessed patients virological success after their antiretroviral therapy was switched following resistance testing. Multilevel logistic regression models with SHCS centre as a random effect were used to investigate the association between the type of resistance test and virological response HIV-1 RNA 50 copies mL or 1.5log reduction . Results Of 1158 individuals with resistance tests 221 with GRT rPRT and 937 with GRT were eligible