Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Amphetamine recapitulates developmental programs in the zebrafish"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Amphetamine recapitulates developmental programs in the zebrafish. | Open Access Amphetamine recapitulates developmental programs in the zebrafish Jean Lud Cadet Address Molecular Neuropsychiatry Branch National Institute on Drug Abuse IRP NIH Biomedical Research Center 251 Bayview Blvd. Baltimore MD 21224 USA. Email jcadet@intra.nida.nih.gov Published 31 July 2009 Genome Biology 2009 10 231 doi 10.1186 gb-2009-10-7-231 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2009 10 7 23 1 2009 BioMed Central Ltd Abstract Addictive drugs hijack the human brain s reward systems. A zebrafish model of addiction has recently been used to query changes in gene expression during this process. The mammalian brain is characterized by neuroanatomical biochemical and molecular complexities that drive cognitive and emotional responses. One of the brain s most notable functions is the evaluation of rewards that impact on daily activities and that help the individual to plan for future rewarding experiences. Unfortunately the brain-rewarding system can be hijacked by psychostimulants that cause drug dependence and addiction in humans. Drug dependence and addiction are complex and vexing neuropsychiatric syndromes characterized by periods of escalated drug use abstinence repeated relapses and an array of adverse medical and biopsychosocial consequences 1 . Although efforts to treat addicted patients have met with some degree of success the molecular neurobiology of these syndromes has remained mysterious. Several animal models have been devised in attempts to dissect the biochemical and molecular pathways that form the pathobiological substrates of drug addiction. Among these is the conditioned place preference CPP which has been used extensively to assess the rewarding effects of both licit and illicit drugs 2 3 . CPP has been used to investigate the motivational properties of an array of pharmacological agents including amphetamine cocaine ethanol marijuana methamphetamine nicotine and .