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Báo cáo y học: "Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds)"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds). | Open Access Research Modified cell cycle status in a mouse model of altered neuronal vulnerability slow Wallerian degeneration Wlds Thomas M Wishart Helen N Pemberton Sally R James Chris J McCabe and Thomas H Gillingwater Addresses Centre for Integrative Physiology University of Edinburgh Medical School Edinburgh EH8 9XD UK. Centre for Neuroscience Research University of Edinburgh Medical School Edinburgh EH8 9XD UK. Division of Medical Sciences Institute of Biomedical Research University of Birmingham Birmingham B15 2TH UK. Correspondence Thomas H Gillingwater. Email T.Gillingwater@ed.ac.uk Published 20 June 2008 Received 21 May 2008 Genome Biology 2008 9 R101 doi l0. ll86 gb-2008-9-6-rl0l Revisedj J. june2008 gy g Accepted 20 June 2008 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 6 Rl0l 2008 Wishart et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Altered neuronal vulnerability underlies many diseases of the human nervous system resulting in degeneration and loss of neurons. The neuroprotective slow Wallerian degeneration Wlds mutation delays degeneration in axonal and synaptic compartments of neurons following a wide range of traumatic and disease-inducing stimuli providing a powerful experimental tool with which to investigate modulation of neuronal vulnerability. Although the mechanisms through which Wlds confers neuroprotection remain unclear a diverse range of downstream modifications incorporating several genes pathways have been implicated. These include the following elevated nicotinamide adenine dinucleotide NAD levels associated with nicotinamide mononucleotide adenylyltransferase l Nmnatl a part of the chimeric .