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Báo cáo y học: "The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains. | Research Open Access The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like p-grasp domains Lakshminarayan M IyerH A Maxwell Burroughs and L Aravind Addresses National Center for Biotechnology Information National Library of Medicine National Institutes of Health Bethesda Maryland 20894 USA. tBioinformatics Program Boston University Cummington Street Boston Massachusetts 02215 USA. H These authors contributed equally to this work. Correspondence LAravind. Email aravind@mail.nih.gov Published 19 July 2006 Genome Biology 2006 7 R60 doi 10.1 186 gb-2006-7-7-r60 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 7 R60 Received 11 April 2006 Revised 12 June 2006 Accepted 6 July 2006 2006 Iyer et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Ubiquitin Ub -mediated signaling is one of the hallmarks of all eukaryotes. Prokaryotic homologs of Ub ThiS and MoaD and E1 ligases have been studied in relation to sulfur incorporation reactions in thiamine and molybdenum tungsten cofactor biosynthesis. However there is no evidence for entire protein modification systems with Ub-like proteins and deconjugation by deubiquitinating enzymes in prokaryotes. Hence the evolutionary assembly of the eukaryotic Ub-signaling apparatus remains unclear. Results We systematically analyzed prokaryotic Ub-related P-grasp fold proteins using sensitive sequence profile searches and structural analysis. Consequently we identified novel Ub-related proteins beyond the characterized ThiS MoaD TGS and YukD domains. To understand their functional associations we sought and recovered several conserved gene neighborhoods and .