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Báo cáo sinh học: "Wnt signaling and the developmental fate of lung cells"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Wnt signaling and the developmental fate of lung cells. | J. Biol. Journal of Biology BioMed Central Research news Wnt signaling and the developmental fate of lung cells Julie Clayton Published 28 June 2004 Journal of Biology 2004 3 9 The electronic version of this article is the complete one and can be found online at http jbiol.com content 3 3 9 2004 BioMed Central Ltd Constitutive activation of the Wnt signaling pathway during lung development in mouse embryos causes some cells to develop a gut-like phenotype. These findings are reminiscent of classical embryological experiments and may have therapeutic implications for pre-cancerous metaplasias. When embryologists began cutting and pasting pieces of chick embryos into new positions back in the 1950s and 1960s they sometimes noticed bizarre changes in tissue types but had little notion of what was going on at a molecular level and even less idea of how to investigate it. Likewise clinicians have puzzled for many years over pre-cancerous conditions called metaplasias in which cells appear in one part of the body that normally belong in another. Neither group could get a handle on how cells escape the usual rules that tell them which types of tissue to form in which part of the body. Now researchers from Duke University Medical Center have contributed to a new awareness of the molecular signals that could explain these phenomena see The bottom line box for a summary of the findings furthermore their data suggest possible ways to manipulate stem cells of adult tissues to make them develop into the tissue of choice for therapeutic purposes. Tadashi Okubo and Brigid Hogan 1 report in this issue of Journal of Biology a surprising result from their studies of the Wnt signaling pathway a central cell-cell signaling pathway during development see the Background box . If a key component of this pathway is expressed in active form in the lungs of developing transgenic mouse embryos cells appear within the The bottom line The Wnt cell-cell signaling pathway is central to many .