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Báo cáo y học: "he Dictyostelium genome encodes numerous RasGEFs with multiple biological roles"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles. | Open Access Research The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles Andrew Wilkins Karol Szafranski Derek J Fraser Deenadayalan Bakthavatsalam Rolf Muller Paul R Fisher Gernot Glockner Ludwig Eichinger Angelika A Noegel and Robert H Insall Addresses School of Biosciences University of Birmingham Birmingham B15 2TT UK. Genome Analysis Institute for Molecular Biotechnology Beutenbergstrasse 11 D-07745 Jena Germany. Department of Microbiology La Trobe University VIC 3086 Australia. Centre for Biochemistry and Centre for Molecular Medicine Cologne Medical Faculty University of Cologne Joseph-Stelzmann-Strasse 52 50931 Cologne Germany. n These authors contributed equally to this work. Correspondence Robert H Insall. E-mail R.H.Insall@bham.ac.uk Published 28 July 2005 Genome Biology 2005 6 R68 doi 10.1 186 gb-2005-6-8-r68 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 8 R68 Received 28 February 2005 Revised 9 May 2005 Accepted 21 June 2005 2005 Wilkins et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Dictyostelium discoideum is a eukaryote with a simple lifestyle and a relatively small genome whose sequence has been fully determined. It is widely used for studies on cell signaling movement and multicellular development. Ras guanine-nucleotide exchange factors RasGEFs are the proteins that activate Ras and thus lie near the top of many signaling pathways. They are particularly important for signaling in development and chemotaxis in many organisms including Dictyostelium. Results We have searched the genome for sequences encoding RasGEFs. Despite its relative simplicity we find that the Dictyostelium .