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Báo cáo y học: "Systematic analysis of transcribed loci in ENCODE regions using RACE sequencing reveals extensive transcription in the human genome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Systematic analysis of transcribed loci in ENCODE regions using RACE sequencing reveals extensive transcription in the human genome. | Open Access Systematic analysis of transcribed loci in ENCODE regions using RACE sequencing reveals extensive transcription in the human genome Jia Qian WuH Jiang DuH Joel Rozowsky Zhengdong Zhang Alexander E Urban Ghia Euskirchen Sherman Weissman Mark Gerstein and Michael Snyder Addresses Molecular Cellular and Developmental Biology Department KBT918 Yale University 266 Whitney Avenue New Haven Connecticut 06511 USA. Computer Science Department Yale University 51 Prospect St. New Haven Connecticut 06511 USA. Molecular Biophysics and Biochemistry Department Yale University 260 Whitney Avenue New Haven Connecticut 06511 USA. Genetics Department Yale University 333 Cedar Street New Haven Connecticut 06511 USA. H These authors contributed equally to this work. Correspondence Michael Snyder. Email Michael.Snyder@yale.edu Published 3 January 2008 Genome Biology 2008 9 R3 doi 10.1186 gb-2008-9-1-r3 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 1 R3 Received 7 November 2007 Revised 6 December 2007 Accepted 3 January 2008 2008 Wu et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recent studies of the mammalian transcriptome have revealed a large number of additional transcribed regions and extraordinary complexity in transcript diversity. However there is still much uncertainty regarding precisely what portion of the genome is transcribed the exact structures of these novel transcripts and the levels of the transcripts produced. Results We have interrogated the transcribed loci in 420 selected ENCyclopedia Of DNA Elements ENCODE regions using rapid amplification of cDNA ends RACE sequencing. We analyzed annotated known gene regions but .