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Báo cáo khoa học: "Replication and drug resistant mutation of HIV-1 subtype B' (Thailand B) variants isolated from HAART treatment individuals in China"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Replication and drug resistant mutation of HIV-1 subtype B' (Thailand B) variants isolated from HAART treatment individuals in China | Virology Journal BioMed Central Open Access Replication and drug resistant mutation of HIV-I subtype B Thailand B variants isolated from HAART treatment individuals in China Jianping Sun1 2 Liying Ma 1 Xiaoling Yu1 3 Yang Huang1 Lin Yuan1 and Yiming Shao 1 Address 1State Key Laboratory for Infection Disease Prevention and Control National Center for AIDS STD Control and Prevention NCAIDS Chinese Center for Disease Control and Prevention China-CDC Beijing 100050 PR China 2AIDS Research Center Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 PR China and 3Southern Medical University School of Pharmaceutical Sciences Guangzhou 510515 PR China Email JianpingSun-sun_jp@126.com LiyingMa - liyingma5566@chinaaids.cn XiaolingYu-xrainbow1103@yahoo.com.cn Yang Huang - huangyuang20@sina.com Lin Yuan - yuj_lin@hotmail.com Yiming Shao - yshao@bbn.cn Corresponding authors Published 18 November 2009 Received 29 December 2008 Accepted 18 November 2009 Virology Journal 2009 6 201 doi l0.ll86 I743-422X-6-201 This article is available from http www.virologyj.com content 6 1 201 2009 Sun et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Drug resistant HIV-1 variants were emergent more and more in AIDS individuals with highly active antiretroviral therapy HAART treatment. Understanding the replication and drug resistant mutation of HIV-1 variants isolated from HAART treatment individuals of China could help to design appropriate therapeutic strategies for these individuals. Methods Use GHOST cell lines to analysis the coreceptor usage of HIV-1 variants. Coculture with PBMCs to analysis the replication capacity. Use RT-PCR to analysis the drug resistant .