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Báo cáo y học: "The change and effect of endothelial progenitor cells in pig with multiple organ dysfunction syndromes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The change and effect of endothelial progenitor cells in pig with multiple organ dysfunction syndromes. | Available online http ccforum.eom content 13 4 R118 Research The change and effect of endothelial progenitor cells in pig with multiple organ dysfunction syndromes Tian Hang Luo Yao Wang Zheng Mao Lu Hong Zhou Xu Chao Xue Jian Wei Bi Li Ye Ma and Guo En Fang Department of General Surgery Changhai Hospital The Second Military Medical University Xiangyin Road Shanghai 200433 PR China Contributed equally Corresponding author Guo En Fang guoenfang@gmail.com Received 16 Apr 2009 Revisions requested 20 May 2009 Revisions received 17 Jun 2009 Accepted 15 Jul 2009 Published 15 Jul 2009 Critical Care 2009 13 R11 8 doi 10.1186 cc7968 This article is online at http ccforum.com content 13 4 R118 2009 Luo et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The dysfunction and decrease of endothelial progenitor cells EPCs may play a very important role in the initiation of organ dysfunction caused by trauma or severe sepsis. We aim to measure the number and function of EPCs in the progression of multiple organ dysfunction syndromes MODS caused by severe sepsis which may help to understand the pathogenesis of MODS by the changing of EPCs. Methods A total of 40 pigs were randomly divided into two groups which were subjected to hemorrhagic shock resuscitation and endotoxemia experimental group n 20 or acted as a control control group n 20 . The number and function of EPCs including adhesive migratory and angiogenesis capacities were analyzed at different times in both groups. Results All the animals in the experimental group developed MODS 100 and 17 of 20 animals 85 died due to MODS the incidence of MODS and death of the animals in the control group were 0 P 0.01 . The number migratory and adhesive .