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Báo cáo hóa học: " Oral Delivery of DMAB-Modified DocetaxelLoaded PLGA-TPGS Nanoparticles for Cancer Chemotherapy"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Oral Delivery of DMAB-Modified DocetaxelLoaded PLGA-TPGS Nanoparticles for Cancer Chemotherapy | Chen et al. Nanoscale Res Lett 2011 6 4 http www.nanoscalereslett.eom content 6 1 4 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Oral Delivery of DMAB-Modified Docetaxel-Loaded PLGA-TPGS Nanoparticles for Cancer Chemotherapy Hongbo Chen1 2t Yi Zheng1 2t Ge Tian3 Yan Tian3 Xiaowei Zeng4 Gan Liu4 Kexin Liu3 Lei Li3 Zhen Li3 Lin Mei1 2 3 Laiqiang Huang1 2 Abstract Three types of nanoparticle formulation from biodegradable PLGA-TPGS random copolymer were developed in this research for oral administration of anticancer drugs which include DMAB-modified PLGA nanoparticles unmodified PLGA-TPGS nanoparticles and DMAB-modified PLGA-TPGS nanoparticles. Firstly the PLGA-TPGS random copolymer was synthesized and characterized. DMAB was used to increase retention time at the cell surface thus increasing the chances of particle uptake and improving oral drug bioavailability. Nanoparticles were found to be of spherical shape with an average particle diameter of around 250 nm. The surface charge of PLGA-TPGS nanoparticles was changed to positive after DMAB modification. The results also showed that the DMAB-modified PLGA-TPGS nanoparticles have significantly higher level of the cellular uptake than that of DMAB-modified PLGA nanoparticles and unmodified PLGA-TPGS nanoparticles. In vitro cytotoxicity experiment showed advantages of the DMAB-modified PLGA-TPGS nanoparticle formulation over commercial Taxotere in terms of cytotoxicity against MCF-7 cells. In conclusion oral chemotherapy by DMAB-modified PLGA-TPGS nanoparticle formulation is an attractive and promising treatment option for patients. Introduction Oncology is one of the few areas of medicine where most patients are treated intravenously rather than receiving oral medications. Oral chemotherapy is attractive because of its convenience and ease of administration particularly in a palliative setting. In addition the oral route facilitates the use of more chronic treatment regimens which .