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Báo cáo y học: "Intra- and inter-individual variation of BIS-index® and during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventional study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Intra- and inter-individual variation of BIS-index® and during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventional study. | Available online http ccforum.eom content 13 1 R20 Research Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam remifentanil and dexmedetomidine remifentanil in healthy volunteers an interventional study Matthias Haenggi1 Heidi Ypparila-Wolters2 Kathrin Hauser1 Claudio Caviezel1 Jukka Takala1 Ilkka Korhonen2 and Stephan M Jakob1 Department of Intensive Care Medicine Bern University Hospital Inselspital and University of Bern Freiburgstrasse CH-3010 Bern Switzerland 2VTT Technical Research Centre of Finland Tekniikankatu 1 Tampere P.O. Box 1300 FI-33101 Tampere Finland Corresponding author Stephan M Jakob stephan.jakob@insel.ch Received 1 Dec 2008 Revisions requested 6 Jan 2009 Revisions received 19 Jan 2009 Accepted 19 Feb 2009 Published 19 Feb 2009 Critical Care 2009 13 R20 doi 10.1186 cc7723 This article is online at http ccforum.com content 13 1 R20 2009 Haenggi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction We studied intra-individual and inter-individual variability of two online sedation monitors BIS and Entropy in volunteers under sedation. Methods Ten healthy volunteers were sedated in a stepwise manner with doses of either midazolam and remifentanil or dexmedetomidine and remifentanil. One week later the procedure was repeated with the remaining drug combination. The doses were adjusted to achieve three different sedation levels Ramsay Scores 2 3 and 4 and controlled by a computer-driven drug-delivery system to maintain stable plasma concentrations of the drugs. At each level of sedation BIS and Entropy response entropy and state entropy values were recorded for 20 minutes. Baseline recordings were obtained before the .