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Báo cáo y học: "An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy. | Clinical and Molecular Allergy BioMed Central Research An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy Linda K Eilertsen1 and Geir Hetland 2 Address Department of Environmental Immunology Norwegian Institute of Public Health Oslo Norway and 2Department of Immunology and Transfusion Medicine Oslo University Hospital Ulleval Oslo Norway Email Linda K Ellertsen - linda.ellertsen@gades.uib.no Geir Hetland - geir.hetland@ulleval.no Corresponding author Open Access Published 5 May 2009 Received 5 February 2009 Clinical and Molecular Allergy 2009 7 6 doi 10.1186 1476-7961-7-6 Accepted 5 May 2009 This article is available from http www.clinicalmolecularallergy.com content 7 1 6 2009 Ellertsen and Hetland licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Agaricus blazei Murill AbM is an edible Brazilian mushroom that has been used in traditional medicine for a range of diseases. It has been shown to have anti-infection and anti-tumor properties in the mouse which are due to induction of Th1 responses. On the other hand IgE-mediated allergy is induced by a Th2 response. Objective Since according to the Th1 Th2 paradigm an increased Th1 response may promote a reduced Th2 response the aim was to examine whether AbM had anti-allergy effects. Methods A mouse model for allergy was employed in which the mice were immunized s.c. with the model allergen ovalbumin OVA . Additionally the animals were given a mushroom extract AndoSan mainly 82 containing AbM but also Hericium erinaceum 15 and Grifola frondosa 3 or PBS p.o. either a day before or 19 days after the immunization. The mice were sacrificed