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Báo cáo y học: "TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells. | Comparative Hepatology BioMed Central Research TGF-p dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells Verena Proell1 Irene Carmona-Cuenca2 Miguel M Murillo2 3 Heidemarie Huber1 Isabel Fabregat3 and Wolfgang Mikulits 1 Open Access Address Department of Medicine I Division Institute of Cancer Research Medical University of Vienna Borschke-Gasse 8a A-1090 Vienna Austria 2Departamento de Bioquímica y Biología Molecular Facultad de Farmacia Universidad Complutense de Madrid Madrid 28040 Spain and 3IDIBELL-Institut de Recerca Oncològica Gran Via s n Km 2.7 L Hospitalet Barcelona Spain Email Verena Proell - verena.proell@meduniwien.ac.at Irene Carmona-Cuenca - ircarcuen@farm.ucm.es Miguel M Murillo - mmurillo@farm.ucm.es Heidemarie Huber - heidemarie.huber@meduniwien.ac.at Isabel Fabregat - ifabregat@iro.es Wolfgang Mikulits - wolfgang.mikulits@meduniwien.ac.at Corresponding author Published 20 February 2007 Received 29 May 2006 Accepted 20 February 2007 Comparative Hepatology 2007 6 1 doi 10.1186 1476-5926-6-1 This article is available from http www.comparative-hepatology.cOm content 6 1 1 2007 Proell et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The activation of hepatic stellate cells HSCs plays a pivotal role during liver injury because the resulting myofibroblasts MFBs are mainly responsible for connective tissue reassembly. MFBs represent therefore cellular targets for anti-fibrotic therapy. In this study we employed activated HSCs termed M1-4HSCs whose transdifferentiation to myofibroblastoid cells named M-HTs depends on transforming growth factor TGF -p. We analyzed the oxidative stress induced by TGF-P and examined