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Báo cáo y học: "Molecular strategies to inhibit HIV-1 replication Morten Hjuler Nielsen, Finn Skou Pedersen and Jørgen "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Molecular strategies to inhibit HIV-1 replication Morten Hjuler Nielsen, Finn Skou Pedersen and Jørgen | Retrovirology BioMed Central Review Molecular strategies to inhibit HIV-1 replication Morten Hjuler Nielsen Finn Skou Pedersen and Jorgen Kjems Open Access Address Department of Molecular Biology University of Aarhus C.F. Mollers Alle Bldg. 130 Room 404 DK-8000 Aarhus C Denmark Email Morten Hjuler Nielsen - mhn@mb.au.dk Finn Skou Pedersen - fsp@mb.au.dk Jorgen Kjems - jk@mb.au.dk Corresponding author Published 16 February 2005 Received 22 December 2004 Retrovirology 2005 2 10 doi 10.1186 1742-4690-2-10 Accepted 16 February 2005 This article is available from http www.retrovirology.cOm content 2 1 10 2005 Nielsen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The human immunodeficiency virus type 1 HIV-1 is the primary cause of the acquired immunodeficiency syndrome AIDS which is a slow progressive and degenerative disease of the human immune system. The pathogenesis of HIV-1 is complex and characterized by the interplay of both viral and host factors. An intense global research effort into understanding the individual steps of the viral replication cycle and the dynamics during an infection has inspired researchers in the development of a wide spectrum of antiviral strategies. Practically every stage in the viral life cycle and every viral gene product is a potential target. In addition several strategies are targeting host proteins that play an essential role in the viral life cycle. This review summarizes the main genetic approaches taken in such antiviral strategies. Introduction HIV-1 is a lentivirus belonging to the retrovirus family. The virus is diploid and contains two plus-stranded RNA copies of its genome. The approximately 9 kb RNA genome encodes at least 9 proteins Gag Pol Env Tat Rev Nef Vif Vpu