tailieunhanh - Báo cáo y học: "What do measurements of molecular biomarkers in different body fluids really tell us"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: What do measurements of molecular biomarkers in different body fluids really tell us. | Poole Arthritis Research Therapy 2011 13 110 http content 13 2 110 EDITORIAL L_ What do measurements of molecular biomarkers in different body fluids really tell us A Robin Poole See related research by Catterall etal. http content 12 6 R229 Abstract Molecular or biochemical biomarkers of joint metabolism offer promise in helping us understand joint pathology its detection and treatment. But they have often been studied alone and in only one body fluid. Although the synovial joint is usually the focus of most arthritis pathology it is often difficult for a variety of reasons to obtain synovial fluid that should best reflect changes in biomarkers related to pathology. It is therefore very important to see whether analyses of more readily obtainable sera and urine also reflect changes in synovial fluid. Catterall and colleagues in a paper in Arthritis Research Therapy that examines very early biomarker changes following joint injury provide us with some insights into these important questions. As the study was very small and examined very early changes following joint injury prior to onset of any recognisable pathology we look forward to future larger biomarker studies of this kind in patients with clinically defined arthritic changes to which we can relate biomarker data. The ability to accurately monitor changes in joint metabolism in vivo that may lead to and predict at a much later date onset of structural pathology detected by imaging is an important challenge for osteoarthritis OA biomarker research. A recent study has examined very early molecular biomarker changes in synovial fluid SF sera and urine following anterior cruciate ligament rupture 1 . This damage often leads many years later to the onset of OA. In animals such an injury can result in OA onset within weeks 2 . As the joint is considered the focus of the pathology it is important to determine whether analyses of more accessible body fluids .