tailieunhanh - Báo cáo y học: "The Hoover's Sign of Pulmonary Disease: Molecular Basis and Clinical Relevance"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The Hoover's Sign of Pulmonary Disease: Molecular Basis and Clinical Relevance. | Clinical and Molecular Allergy BioMed Central Open Access Review The Hoover s Sign of Pulmonary Disease Molecular Basis and Clinical Relevance Chambless R Johnston III 1 Narayanaswamy Krishnaswamy1 and Guha Krishnaswamy1 2 Address Department of Internal Medicine Quillen College of Medicine and James. H. Quillen VA Medical Center Johnson City TN 37614-0622 USA and 2Department of Medicine Division of Allergy and Clinical Immunology James. H. Quillen VA Medical Center Mountain Home TN 37684 USA Email Chambless R Johnston - chamj22@ Narayanaswamy Krishnaswamy - KRISHNAS@ Guha Krishnaswamy - KRISHNAS@ Corresponding author Published 5 September 2008 Received 28 December 2007 _A- Accepted 5 September 2008 Clinical and Molecular Allergy 2008 6 8 doi 1476-7961-6-8 This article is available from http content 6 1 8 2008 Johnston et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ In the 1920 s Hoover described a sign that could be considered a marker of severe airway obstruction. While readily recognizable at the bedside it may easily be missed on a cursory physical examination. Hoover s sign refers to the inspiratory retraction of the lower intercostal spaces that occurs with obstructive airway disease. It results from alteration in dynamics of diaphragmatic contraction due to hyperinflation resulting in traction on the rib margins by the flattened diaphragm. The sign is reported to have a sensitivity of 58 and specificity of 86 for detection of airway obstruction. Seen in up to 70 of patients with severe obstruction this sign is associated with a patient s body .