Kinh doanh - Marketing
Kinh tế quản lý
Biểu mẫu - Văn bản
Tài chính - Ngân hàng
Công nghệ thông tin
Tiếng anh ngoại ngữ
Kĩ thuật công nghệ
Khoa học tự nhiên
Khoa học xã hội
Văn hóa nghệ thuật
Sức khỏe - Y tế
Văn bản luật
Nông Lâm Ngư
Kỹ năng mềm
Luận văn - Báo cáo
Giải trí - Thư giãn
Tài liệu phổ thông
Văn mẫu
Giới thiệu
Đăng ký
Đăng nhập
Tìm
Danh mục
Kinh doanh - Marketing
Kinh tế quản lý
Biểu mẫu - Văn bản
Tài chính - Ngân hàng
Công nghệ thông tin
Tiếng anh ngoại ngữ
Kĩ thuật công nghệ
Khoa học tự nhiên
Khoa học xã hội
Văn hóa nghệ thuật
Y tế sức khỏe
Văn bản luật
Nông lâm ngư
Kĩ năng mềm
Luận văn - Báo cáo
Giải trí - Thư giãn
Tài liệu phổ thông
Văn mẫu
Thông tin
Điều khoản sử dụng
Quy định bảo mật
Quy chế hoạt động
Chính sách bản quyền
Giới thiệu
Đăng ký
Đăng nhập
0
Trang chủ
Y Tế - Sức Khoẻ
Y khoa - Dược
High expression of eIF4E is associated with tumor macrophage infltration and leads to poor prognosis in breast cancer
Đang chuẩn bị liên kết để tải về tài liệu:
High expression of eIF4E is associated with tumor macrophage infltration and leads to poor prognosis in breast cancer
Ý Lan
55
20
pdf
Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
The expression and activation of eukaryotic translation initiation factor 4E (eIF4E) is associated with cell transformation and tumor initiation, but the functional role and the mechanism whereby it drives immune cell infltration in breast cancer (BRCA) remain uncertain. | Li et al. BMC Cancer 2021 21 1305 https doi.org 10.1186 s12885-021-09010-0 RESEARCH Open Access High expression of eIF4E is associated with tumor macrophage infiltration and leads to poor prognosis in breast cancer Fan Li1 Huizhi Sun1 2 Yue Li1 Xiaoyu Bai1 Xueyi Dong1 3 Nan Zhao1 3 Jie Meng1 3 Baocun Sun1 2 and Danfang Zhang1 3 Abstract Background The expression and activation of eukaryotic translation initiation factor 4E eIF4E is associated with cell transformation and tumor initiation but the functional role and the mechanism whereby it drives immune cell infiltra- tion in breast cancer BRCA remain uncertain. Methods Oncomine Timer and UALCAN were used to analyze the expression of eIF4E in various cancers. PrognoS- can Kaplan Meier plotter and GEPIA were utilized to analyze the prognostic value of eIF4E in select cancers. In vitro cell experiments were used to verify the role of eIF4E in promoting the progression of BRCA. ImmuCellAI and TIMER database were used to explore the relationship between eIF4E and tumor infiltrating immune cells. The expression of a macrophage marker CD68 and an M2-type marker CD163 was evaluated using immunohistochemistry in 50 invasive BRCA samples on tissue microarrays. The Human Protein Atlas HPA database was used to show the expression of eIF4E and related immune markers. LinkedOmics and NetworkAnalyst were used to build the signaling network. Results Through multiple dataset mining we found that the expression of eIF4E in BRCA was higher than that in normal tissues and patients with increased eIF4E expression had poorer survival and a higher cumulative recurrence rate in BRCA. At the cellular level BRCA cell migration and invasion were significantly inhibited after eIF4E expression was inhibited by siRNA. Immune infiltration analysis showed that the eIF4E expression level was significantly associ- ated with the tumor purity and immune infiltration levels of different immune cells in BRCA. The results from immu- nohistochemical .
TÀI LIỆU LIÊN QUAN
Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer
Transcriptome analysis revealed expression of genes related to anthocyanin biosynthesis in eggplant (Solanum melongena L.) under high-temperature stress
Heterologous expression of Aspergillus aculeatus endo-polygalacturonase in Pichia pastoris by high cell density fermentation and its application in textile scouring
Stable high-level expression of factor VIII in Chinese hamster ovary cells in improved elongation factor-1 alpha-based system
Clinical significance of FBXO17 gene expression in high-grade glioma
Identification of transcription factors interacting with a 1274 bp promoter of MaPIP1;1 which confers high-level gene expression and drought stress Inducibility in transgenic Arabidopsis thaliana
Gene expression variations in high-altitude adaptation: A case study of the Asiatic toad (Bufo gargarizans)
Cloning and expression of the dengue virus non structural protein 1 (NS1) in E. coli
High dimensional model representation of log-likelihood ratio: Binary classification with expression data
Prognostic value of high FoxC2 expression in resectable non-small cell lung cancer, alone or in combination with E-cadherin expression
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.