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An ultrasensitive electrochemical immunosensor platform based on disposable ITO electrode modified by 3-CPTMS for early detection of parathyroid hormone

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Parathyroid hormone (PTH) is a polypeptide containing 84 amino acids secreted by cells of the parathyroid glands. Imbalances of parathyroid levels cause medical problems such as osteoporosis, mental disorders, pancreatitis, kidney stones, cancer, and other symptoms. In this study, we aimed to design an ultrasensitive electrochemical immunosensor for PTH detection. Indium tin oxide (ITO) was used as an electrode for electrochemical impedance spectroscopy (EIS) measurements. ITO sheets were modified by using 3-cyanopropyltrimethoxysilane (3-CPTMS) selfassembled monolayers (SAMs) for immobilizing the anti-PTH antibody via covalent interactions. |

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An ultrasensitive electrochemical immunosensor platform based on disposable ITO electrode modified by 3-CPTMS for early detection of parathyroid hormone