tailieunhanh - Báo cáo y học: "Quantification of the glycogen cascade system: the ultrasensitive responses of liver glycogen synthase and muscle phosphorylase are due to distinctive regulatory designs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Quantification of the glycogen cascade system: the ultrasensitive responses of liver glycogen synthase and muscle phosphorylase are due to distinctive regulatory designs | Theoretical Biology and Medical Modelling BioMed Central Research Open Access Quantification of the glycogen cascade system the ultrasensitive responses of liver glycogen synthase and muscle phosphorylase are due to distinctive regulatory designs Vivek K Mutalik and KVVenkatesh Address Department of Chemical Engineering and School of Biosciences and Bioengineering Indian Institute of Technology Bombay Powai Mumbai-400 076 India Email Vivek K Mutalik - vivekm@ KV Venkatesh - venks@ Corresponding author Published 20 May 2005 Received 15 February 2005 Theoretical Biology and Medical Modelling 2005 2 19 doi l742-4682-2-AcCepted 20 May 2005 19 This article is available from http content 2 1 19 2005 Mutalik and Venkatesh licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Signaling pathways include intricate networks of reversible covalent modification cycles. Such multicyclic enzyme cascades amplify the input stimulus cause integration of multiple signals and exhibit sensitive output responses. Regulation of glycogen synthase and phosphorylase by reversible covalent modification cycles exemplifies signal transduction by enzyme cascades. Although this system for regulating glycogen synthesis and breakdown appears similar in all tissues subtle differences have been identified. For example phosphatase-1 a dephosphorylating enzyme of the system is regulated quite differently in muscle and liver. Do these small differences in regulatory architecture affect the overall performance of the glycogen cascade in a specific tissue We address this question by analyzing the regulatory structure of the glycogen cascade system in liver and muscle cells at steady state. Results

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