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The effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: A genetic study

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Endotoxins stimulate T helper 1 cell maturation and send a negative signal to T helper 2 polarisation. This causes a decrease IgE levels and prevents atopy (Hygiene hypothesis). It is shown that this response is under genetic control by polymorphisms in CD14 and TLR4 genes in some researchs. |

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