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In vivo dual targeting of the oncogenic Ether-àgo-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors

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The oncogenic ether-à-go-go-1 potassium channel (EAG1) activity and expression are necessary for cell cycle progression and tumorigenesis. The active vitamin D metabolite, calcitriol, and astemizole, a promising antineoplastic drug, target EAG1 by inhibiting its expression and blocking ion currents, respectively. |