tailieunhanh - Anticlastogenic effect of Euphorbia hirta using in vivo rodent micronucleus assay
Aqueous extracts of Euphorbia hirta were used to study the anticlastogenic activity by in vivo rodent micronucleus assay. Mice were administrated two doses, 250 mg/kg and 500 mg/kg orally for a period of seven days and at the end of the seventh day, cyclophosphamide (50 m/kg) was given intraperitoneally. Bone marrow sample were analysed for cytotoxicity and micronucleus. Both the doses were not cytotoxic and clastogenic. There was a significant reduction in the micronucleus formation in bone marrow indicating the anticlastogenic activity of E. hirta. | Anticlastogenic effect of Euphorbia hirta using in vivo rodent micronucleus assay
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