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Antagonism of Sorafenib and Regorafenib actions by platelet factors in hepatocellular carcinoma cell lines

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Platelets are frequently altered in hepatocellular carcinoma (HCC) patients. Platelet lysates (hPL) can enhance HCC cell growth and decrease apoptosis. The aims were to evaluate whether hPL can modulate the actions of Sorafenib or Regorafenib, two clinical HCC multikinase antagonists. |

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