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Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA

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Blood-based methods using cell-free DNA (cfDNA) are under development as an alternative to existing screening tests. However, early-stage detection of cancer using tumor-derived cfDNA has proven challenging because of the small proportion of cfDNA derived from tumor tissue in early-stage disease. | Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA