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Novel membrane sensor for determination of lamotrigine in pharmaceuticals and urine

Lamotrigine (LMT), chemically known as [6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine], is a broad spectrum antiepileptic drug, used as monotherapy and as an adjunct with other antiepileptic drugs for treatment of partial and generalized toxic-clonic seizures. | Novel membrane sensor for determination of lamotrigine in pharmaceuticals and urine Current Chemistry Letters 8 2019 87 96 Contents lists available at GrowingScience Current Chemistry Letters homepage www.GrowingScience.com Novel membrane sensor for determination of lamotrigine in pharmaceuticals and urine N. Rajendraprasada a PG Department of Chemistry JSS College of Arts Commerce and Science Autonomous under University of Mysore B N Road Mysuru-570 025 Karnataka India CHRONICLE ABSTRACT Article history Lamotrigine LMT chemically known as 6- 2 3-dichlorophenyl -1 2 4-triazine-3 5- Received July 28 2018 diamine is a broad spectrum antiepileptic drug used as monotherapy and as an adjunct with Received in revised form other antiepileptic drugs for treatment of partial and generalized toxic-clonic seizures. It is February 20 2019 used to treat neurological lesions and as a tranquilizer. A selective electrochemical membrane Accepted February 20 2019 sensor has been developed and validated for determination of LMT. The membrane Available online constructed using LMT and molybdophosphoric acid in THF and PVC is applicable for the February 22 2019 detection of 5 10-4 to 9 10-3 M LMT in the pH range between 4.6 and 5.8 with the Nernstian Keywords slope of 57.14 1 mV decade. The regression coefficient value of 0.9932 showed a good linear Membrane sensor correlation between the concentrations of LMT and measured cell potentials. The limits of Lamotrigine detection LOD and quantification LOQ values for the fabricated sensor were 1.3 10-5 and Potentiometric determination 4 10-5 M LMT respectively. Various experimental conditions were optimized to reach the Pharmaceuticals effective performance characteristics of the sensor. The effect of various cations anions and Spiked human urine organic species on the performance of sensor was studied by following standard-addition procedure. The results revealed no such variations due to presence of foreign ions or species. The .