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Design of a generic CRISPR-Cas9 approach using the same sgRNA to perform gene editing at distinct loci
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The CRISPR/Cas (clustered regularly interspaced short palindromic repeat and CRISPR-associated nucleases) based technologies have revolutionized genome engineering. While their use for prokaryotic genome editing is expanding, some limitations remain such as possible off-target effects and design constraints. | Design of a generic CRISPR-Cas9 approach using the same sgRNA to perform gene editing at distinct loci