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Terpenoids from Dacrycarpus imbricatus

The phytochemical investigation of the hexane extract from the twigs and leaves of Dacrycarpus imbricatus (Blume) de Laub led to the isolation of a rare sesquiterpene, spathulenol (1) along with three diterpenes named pimaric acid (2), trans-communic acid (3) and cis-communic acid (4). Their structures were determined by combination of spectral analysis and comparison with reported data. This is the first report on isolation of compound 1 from the Podocarpaceae family. | Vietnam Journal of Chemistry, International Edition, 55(6): 734-737, 2017 DOI: 10.15625/2525-2321.2017-00536 Terpenoids from Dacrycarpus imbricatus Dang Viet Hau1,2, Nguyen Thanh Tam1,2, Nguyen Thi Hoang Anh1,2, Tran Duc Quan1, Dao Duc Thien1, Le Thi Hong Nhung3, Bui Xuan Tinh4, Nguyen Le Tuan5, Tran Van Loc1, Tran Van Sung1, Trinh Thi Thuy1,2* 1 Institute of Chemistry, Vietnam Academy of Science and Technology (VAST) 2 Graduate University of Science and Technology, VAST 3 4 University of Industry Quang Trung University 5 Qui Nhon University Received 19 October 2017; Accepted for publication 29 December 2017 Abstract The phytochemical investigation of the hexane extract from the twigs and leaves of Dacrycarpus imbricatus (Blume) de Laub led to the isolation of a rare sesquiterpene, spathulenol (1) along with three diterpenes named pimaric acid (2), trans-communic acid (3) and cis-communic acid (4). Their structures were determined by combination of spectral analysis and comparison with reported data. This is the first report on isolation of compound 1 from the Podocarpaceae family. Keywords. Dacrycarpus imbricatus, spathulenol, pimaric acid, communic acid. 1. INTRODUCTION Dacrycarpus imbricatus (Blume) de Laub (Podocarpus kawaii Hayata) is a coniferous tree, up to 40 m tall with red brown bark, belonging to Podocarpaceae family. It is mainly distributed in the West Pacific islands near China and Viet Nam. This tree is classified as 'Least Concern' in the IUCN Red List of Threatened Species (2011) [1]. Its timber had been used in construction, for furniture, firewood and in some areas cultivated as ornamental tree. In our previous paper, we described the isolation and identification of 20-hydroxyecdysone from the bark of D. imbricatus and its effect on OCI-AML cell proliferation in vitro [2]. In the course of our continuing search for the bioactive constituents of this plant, a rare sesquiterpene, spathulenol (1) and three diterpenes:pimaric acid (2), .